Product Description WBP (Non-invasive)
The non-invasive respiratory testing system (Whole-body Plethysmography System) for unrestrained animals developed by Tow-Int Tech can measure respiratory parameters of conscious, freely moving animals, such as ASD airway hyperresponsiveness (AHR), tidal volume, and sleep monitoring of mice, Penh airway resistance, mice lung function indicators, etc. WBP avoids the trauma of aerosol tube incisions and the effects of anesthesia, making the whole experimental process simpler. It is used to study the reaction of animal models to drugs and the pharmacology and toxicology of respiratory drugs, especially suitable for the rapid initial screening tests of a large number of animal models, long-term follow-up research, and repetitive screenings.
Product Features WBP
- No operation is required, and the instrument is easy to use
- Multi-channel simultaneous monitoring
- It can be used to study animal respiration in a natural state and conduct long-term follow-up experiments, which makes it suitable for the initial screening of drugs.
- The drug aerosol atomization module is available
- Automatic calibration function
- There are drinking water and food ports for long-term continuous monitoring
- Optional functions are available, for example, the measurements of ECG, blood pressure, body temperature, heart rate, and other vital signs, which can be combined with implantable telemetry equipment
- Equipped with analysis software, data can be saved in Excel or TXT format
Test Parameters
- Ti: Inspiratory Time (s)
- Te: Expiratory Time (s)
- PIF: Peak Inspiratory Flow (ml/s)
- PEF: Peak Expiratory Flow (ml/s)
- Volbal: Difference between Inspiratory/Expiratory Volume
- F: Breath Frequency (breaths per minute)
- Vt:Tidal Volume（ml）
- Mv:Minute Ventilation（ml）
- AV:Accumulated Volume（ml）
- EF50: Mid-tidal Expiratory Flow
- EIP: End-inspiratory Pause (Invasive Method)
- EEP: End-expiatory Pause (Invasive Method)
- TR: Relax Time
- PenH: Enhanced Pause
- Rpef: Ratio of Time to Peak Expiratory Flow
Applications
- Researches on various respiratory diseases, such as asthma, pulmonary fibrosis, lung injury, ARDS, lung cancer, etc.
- Safety pharmacology: the effect of drugs on the respiratory system
- Sleep apnea: monitor animal hypopnea, obstructive apnea, etc.
- Environmental Toxicology: The impact of environmental pollutants on animal respiration
- Inhalation Toxicology: Toxic effects of toxic substances on the respiratory system
- High altitude medicine: The influence of high altitude environment on the respiratory system
- Other occasions where respiratory parameters need to be evaluated
Configuration
| Name | Model | Description | Unit |
| Whole-body Plethysmography System | WBP-4M | 4-channel, mice | Set |
| Whole-body Plethysmography System | WBP-4R | 4-channel, rats | Set |
| Whole-body Plethysmography System | WBP-4MR | 4-channel, mice/rats | Set |
| Whole-body Plethysmography System | WBP-8M | 8-channel, mice | Set |
| Whole-body Plethysmography System | WBP-8R | 8-channel, rats | Set |
| Whole-body Plethysmography System | WBP-8MR | 8-channel, mice/rats | Set |
End-Users List
| Shanghai Central Hospital | Shanghai Ruijin Hospital | Huashan Hospital Affiliated to Fudan University | Shanghai Institute of Pharmaceutical Sciences |
| China Pharmaceutical University | Guangdong Pharmaceutical University | Chongqing Medical University | The Third People’s Hospital of Chengdu |
| Beijing University of Chinese Medicine | Institute of Urban Environment, Chinese Academy of Sciences | Nanjing University | West China Hospital, Sichuan University |
| Suzhou University | University of TCM | The First Affiliated Hospital of Anhui Medical University | Qingdao Municipal Hospital |
| Lanzhou University | University of South China | Ningxia Medical University |
References
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[40] Tsentsevitsky A N, Sibgatullina G V, Odoshivkina Y G, et al. Functional and Structural Changes in Diaphragm Neuromuscular Junctions in Early Aging[J]. International Journal of Molecular Sciences, 2024, 25(16): 8959.
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[2] Jiang C, Huang H, Yang X, et al. Targeting mitochondrial dynamics of morphine-responsive dopaminergic neurons ameliorates opiate withdrawal[J]. The Journal of Clinical Investigation (IF 19.5), 2024.
[3] Wang Z, Miao Z, Cao Z, et al. Mild Hyperthermia‐Assisted Coaxial Electrospun Nanofiber Patches for Epicutaneous Allergen‐Specific Immunotherapy[J]. Advanced Functional Materials (IF 19.0), 2025: e09955.
[4] Dong S, Fang H, Zhu J, et al. Inhalable siRNA Targeting IL-11 Nanoparticles Significantly Inhibit Bleomycin-Induced Pulmonary Fibrosis[J]. ACS nano (IF 15.8), 2025.
[5] Chen J, Wang J, Zheng W, et al. Brain–cervical lymph node crosstalk contributes to brain injury induced by subarachnoid hemorrhage in mice[J]. Nature Communications (IF 15.7), 2025, 16(1): 8551.
[6] Wang Y, Zhao Q, Zhang Q, et al. Targeted Delivery of CNS‐Specific Hesperidin as a Leptin Sensitizer for Treating Obesity‐Associated Sleep‐Disordered Breathing[J]. Advanced Science (14.1), 2025, 12(45): e06182.
[7] Wang Z, Lu X, Wu L, et al. Co-delivery of targeted hypoallergens and resiquimod powders using silk fibroin microneedles for effective allergen-specific immunotherapy[J]. Theranostics (IF 13.3), 2025, 15(16): 8096.
[8] Liu Y, Li G, Xiong A, et al. Fine particulate matter exacerbates asthma by activating STC2-mediated mitophagy through METTL3/YTHDF2-dependent m6A methylation[J]. Journal of Hazardous Materials (IF12.2), 2025: 138854.
[9] Li H, Liu S, Dai W, et al. Pressure-sensitive multivesicular liposomes as a smart drug-delivery system for high-altitude pulmonary edema[J]. Journal of Controlled Release (IF 11.5), 2024, 365: 301-316.
[10] Hou T, Zhu L, Zhang Y, et al. Lipid peroxidation triggered by the degradation of xCT contributes to gasdermin D-mediated pyroptosis in COPD[J]. Redox Biology (IF 10.1), 2024, 77: 103388.
[11] Luo L, Qin Z, Chen M, et al. γ-Aminobutyric acid–mediated parafacial zone: Integrating consciousness and respiratory control in sevoflurane anesthesia[J]. Anesthesiology (IF 9.1), 2025, 144(1): 116.
[12] Duan L L, Cai P, Li Z S, et al. Role of the supramammillary nucleus–medial septum glutamatergic pathway in mediating the effects of isoflurane anesthesia[J]. Anesthesiology (IF 9.1), 2025, 143(4): 944.
[13] Wei X, Cao X, Xu C, et al. Revolutionizing antibiotic therapy: polymyxin B and Fe2+-enriched liposomal carrier harness novel bacterial ferroptosis mechanism to combat resistant infections[J]. Journal of Pharmaceutical Analysis, 2025: 101293.
[14] Zhou W, Zhou Y, Zhang S, et al. Gut microbiota’s role in high-altitude cognitive impairment: The therapeutic potential of Clostridium sp. supplementation[J]. Science China Life Sciences, 2025, 68(4): 1132-1148.
[15] Liu J, Gao J, Xiong A, et al. Exploring Cistanche’s therapeutic potential and molecular mechanisms in asthma treatment[J]. Phytomedicine, 2025, 136: 156265.
[16] Wang X, Zhao H, Lin W, et al. Panax notoginseng saponins ameliorate LPS-induced acute lung injury by promoting STAT6-mediated M2-like macrophage polarization[J]. Phytomedicine, 2025, 139: 156513.
[17] Jiang J, Ai S, Yuan C, et al. Dysfunction of cholinergic neuron in nucleus ambiguous aggravates sepsis-induced lung injury via a GluA1-dependment mechanism[J]. Brain, Behavior, and Immunity, 2025.
[18] Xu Z, Wu Y, Zhao X, et al. Integrating nontargeted metabolomics and RNA sequencing of dexamethasone-treated and untreated asthmatic mice reveals changes of amino acids and aminoacyl-tRNA in group 2 innate lymphoid cells[J]. International Journal of Biological Macromolecules, 2024, 283: 137630.
[19] Su J, Tu Y, Hu X, et al. Ambient PM2. 5 orchestrates M1 polarization of alveolar macrophages via activating glutaminase 1-mediated glutaminolysis in acute lung injury[J]. Environmental Pollution, 2025, 366: 125467.
[20] Shan C, Li W, Sun Y, et al. Benzo (a) pyrene exposure aggravates airway remodeling in asthma by activating AhR-GDF15 pathway in epithelial cells[J]. Environmental Pollution, 2025: 127557.
[21] Zhang M, Xu B, Li N, et al. All-Hydrocarbon Stapled Peptide Multifunctional Agonists at Opioid and Neuropeptide FF Receptors: Highly Potent, Long-Lasting Brain Permeant Analgesics with Diminished Side Effects[J]. Journal of Medicinal Chemistry, 2023.
[22] Long Y, Ang Y, Chen W, et al. Hydrogen alleviates impaired lung epithelial barrier in acute respiratory distress syndrome via inhibiting Drp1-mediated mitochondrial fission through the Trx1 pathway[J]. Free Radical Biology and Medicine, 2024, 218: 132-148.
[23] Wang Y, Liu X, Zhang Q, et al. Bioluminescence-optogenetics-mediated gene therapy in a sleep-disordered breathing mouse model[J]. Biomedicine & Pharmacotherapy, 2024, 178: 117159.
[24] Tabynov K, Tailakova E, Rakhmatullayeva G, et al. Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma[J]. npj Vaccines, 2025, 10(1): 66.
[25] Jiang Y, Zhang Y, Wang X, et al. Phosphatase PHLPP1 is an alveolar-macrophage-intrinsic transcriptional checkpoint controlling pulmonary fibrosis[J]. Cell Reports, 2025, 44(3).
[26] Liu S, Chu J, Yin X, et al. The adeno associated viral vectored Dp12S vaccine effective alleviation of asthma symptoms in mice[J]. npj Vaccines, 2025.
[27] Jin M, Liu J, Shao M, et al. Chitosan Nanoparticles for Pulmonary Delivery of Curcumin/Nintedanib to Treat Pulmonary Fibrosis[J]. International Journal of Nanomedicine, 2025: 12959-12973.
[28] Xiong A, He X, Liu S, et al. Oxidative stress-mediated activation of FTO exacerbates impairment of the epithelial barrier by up-regulating IKBKB via N6-methyladenosine-dependent mRNA stability in asthmatic mice exposed to PM2. 5[J]. Ecotoxicology and Environmental Safety, 2024, 272: 116067.
[29] Jia X, Liu S, Sun C, et al. METTL16 controls airway inflammations in smoking-induced COPD via regulating glutamine metabolism[J]. Ecotoxicology and Environmental Safety, 2025, 289: 117518.
[30] Lu X, Tan Z X, Yao Y X, et al. Inhaling arsenic aggravates airway hyperreactivity by upregulating PNEC-sourced 5-HT in OVA-induced allergic asthma[J]. Ecotoxicology and Environmental Safety, 2025, 290: 117764.
[31] Li Q, Ang Y, Zhou Q, et al. Coral calcium hydride promotes peripheral mitochondrial division and reduces AT-II cells damage in ARDS via activation of the Trx2/Myo19/Drp1 pathway[J]. Journal of Pharmaceutical Analysis, 2024: 101039.
[32] Zhang X, Hu T, Yu X, et al. Human umbilical cord mesenchymal stem cells improve lung function in chronic obstructive pulmonary disease rat model through regulating lung microbiota[J]. Stem Cells, 2024: sxae007.
[33] Akhtemova N, Sergazina A, Bolatbekov T, et al. The role of major allergens Art v 1 and Art v 3 in Artemisia pollen-induced asthma: a mouse model study[J]. Frontiers in Immunology, 2025, 16: 1590791.
[34] Tabynov K, Nedushenko I, Tailakova E, et al. Intranasal monoclonal antibodies to mugwort pollen reduce allergic inflammation in a mouse model of allergic rhinitis and asthma[J]. Frontiers in Immunology, 2025, 16: 1595659.
[35] Zhang Y, Jiang M, Xiong Y, et al. Integrated analysis of ATAC-seq and RNA-seq unveils the role of ferroptosis in PM2. 5-induced asthma exacerbation[J]. International Immunopharmacology, 2023, 125: 111209.
[36] Yao W, Huang S X, Zhang L, et al. Central amygdala somatostatin neurons modulate stress-induced sleep-onset insomnia[J]. Communications Biology, 2025, 8(1): 381.
[37] Lin Y, Wu Y, Ma F, et al. Exploration of the mechanism of Qi-Xian decoction in asthmatic mice using metabolomics combined with network pharmacology[J]. Frontiers in Molecular Biosciences, 2023, 10.
[38] Yang D, Li Y, Liu T, et al. IL‐1β promotes IL‐17A production of ILC3s to aggravate neutrophilic airway inflammation in mice[J]. Immunology, 2025, 176(1): 16-32.
[39] Zhang Y, Yang Y, Liang H, et al. Nobiletin, as a Novel PDE4B Inhibitor, Alleviates Asthma Symptoms by Activating the cAMP-PKA-CREB Signaling Pathway[J]. International Journal of Molecular Sciences, 2024, 25(19): 10406.
[40] Tsentsevitsky A N, Sibgatullina G V, Odoshivkina Y G, et al. Functional and Structural Changes in Diaphragm Neuromuscular Junctions in Early Aging[J]. International Journal of Molecular Sciences, 2024, 25(16): 8959.
[41] Ma J, Ni Z, Chen Q, et al. Exploring the kidney-tonifying effect of Qi-Xian decoction for asthma treatment by modulating the proliferation and migration of endogenous BMSCs[J]. Chinese Journal of Natural Medicines, 2025, 23(12): 100009.
[42] Liu K, Gu Y, Gu S, et al. Trim27 aggravates airway inflammation and oxidative stress in asthmatic mice via potentiating the NLRP3 inflammasome[J]. International Immunopharmacology, 2024, 134: 112199.
[43] Yuan Z, Wang Q, Tan Y, et al. Methylprednisolone alleviates lung injury in sepsis by regulating miR-151-5p/USP38 pathway[J]. International Immunopharmacology, 2024, 138: 112548.
[44] Wang Y, Peng M, Yang X, et al. Total alkaloids in Fritillaria cirrhosa D. Don alleviate OVA-induced allergic asthma by inhibiting M2 macrophage polarization[J]. Journal of Ethnopharmacology, 2025, 337: 118935.
[45] He J, Li J, Lin Q, et al. Anti-CD20 treatment attenuates Th2 cell responses: implications for the role of lung follicular mature B cells in the asthmatic mice[J]. Inflammation Research, 2024, 73(3): 433-446
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